Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations
نویسندگان
چکیده
منابع مشابه
cyp51A-based mechanisms of Aspergillus fumigatus azole
72 Since the mid-1990s, a steady increase in the occurrence of itraconazole resistant Aspergillus 73 fumigatus isolates has been observed in clinical contexts leading to therapeutic failure in the 74 treatment of aspergillosis. This increase has been predominantly linked to a single allele of 75 the cyp51A gene, termed ‘TR/L98H’ which is thought to have arisen through the use of 76 agricultural...
متن کاملAzole-Resistant Aspergillus fumigatus, Iran
ics of antibodies against hypodermin C in reindeer infested with the reindeer warble fly, Hypoderma tarandi. Human ophthalmomyiasis interna caused by Hypoderma tarandi, northern Canada. Abiotic factors influencing embry-onic development, egg hatching, and larval orientation in the reindeer war-ble fly, Hypoderma tarandi. Suspected lice eggs in the hair of a boy revealed dangerous parasite [in S...
متن کاملMultiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.
Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previousl...
متن کاملAzole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan.
Azole antifungals are used not only clinically for fungal infections but also used as agricultural fungicides. Recently, azole-resistant Aspergillus fumigatus containing a tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) appears in the environment in Eurasia, especially in several European countries. Although azole fungicides have been used in Japan, espec...
متن کاملExamination of cyp51A and cyp51B expression level of the first Polish azole resistant clinical Aspergillus fumigatus isolate.
Aspergillus fumigatus is one of the most prevalent airborne fungal pathogens causing infections worldwide. Most A. fumigatus strains are susceptible to azoles, which are administered as the first line therapeutics. However, during last decade the acquired resistance to triazoles by these species has been described. There is a number of publications concerning the examination of clinical A. fumi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Fungi
سال: 2021
ISSN: 2309-608X
DOI: 10.3390/jof7010022